Gene–environment interactions begin at conception to influence maternal/placental/fetal
triads, neonates, and children with short-and long-term effects on brain development. Life …

The journey of human development from a single-cell zygote to a term infant is complex
process. Early research into copy number variants and highly penetrant single-gene …

Developmental and/or epileptic encephalopathies (DEEs) are a group of devastating
genetic disorders, resulting in early-onset, therapy-resistant seizures and developmental …

Purpose Pregnancy loss ranging from spontaneous abortion (SAB) to stillbirth can result
from monogenic causes of Mendelian inheritance. This study evaluated the clinical …

The term multilocus imprinting disturbance (MLID) describes the aberrant methylation of
multiple imprinted loci in the genome, and MLID occurs in patients suffering from imprinting …

Purpose Existing resources that characterize the essentiality status of genes are based on
either proliferation assessment in human cell lines, viability evaluation in mouse knockouts …

Recurrent pregnancy loss (RPL) is a common reproductive problem affecting around 5% of
couples worldwide. At present, about half of RPL cases remained unexplained. Previous …

Recurrent pregnancy loss (RPL) is affecting 3–5% of the women who are expecting to have
babies annually. However, the molecular changes of RPL patients have not been well …

Proteinopathies are characterized by aging related accumulation of misfolded protein
aggregates. Irreversible covalent modifications of aging proteins may significantly affect the …

Spontaneous abortion is the most common complication in early pregnancy, the exact
etiology of most cases cannot be determined. Emerging studies suggest that mutations in …