Thiol peroxidases comprise glutathione peroxidases (GPx) and peroxiredoxins (Prx). The
enzymes of both families reduce hydroperoxides with thiols by enzyme-substitution …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Radiation damage inflicted during diffraction data collection in macromolecular
crystallography has re-emerged in the last decade as a major experimental and …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of
proliferative processes, and in trypanosomatid protozoa play an additional role in the …

X-ray radiation damage to cryocooled (∼ 100K) macromolecular crystals has emerged as a
general problem, especially since the advent of third generation synchrotron undulator …

Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating
the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member …

Oxidative stress plays an important role in the modulation of several important physiological
functions. On the other side, oxidative stress is accountable for development of many …

The bifunctional trypanothione synthetase-amidase catalyzes biosynthesis and hydrolysis of
the glutathione-spermidine adduct trypanothione, the principal intracellular thiol-redox …

Trypanosomes and Leishmania, the causative agents of severe tropical diseases, employ 2-
Cys-peroxiredoxins together with cysteine-homologues of glutathione peroxidases and …