[HTML][HTML] Hypertension-induced cognitive impairment: from pathophysiology to public health
Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related …
Aging is associated with increased oxidative stress in vascular endothelial and smooth
muscle cells, which contribute to the development of a wide range of diseases affecting the …
muscle cells, which contribute to the development of a wide range of diseases affecting the …
Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a …
T Kiss, P Balasubramanian, MN Valcarcel-Ares… - Geroscience, 2019 - Springer
Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular
rarefaction and development of vascular cognitive impairment and dementia (VCID) in the …
rarefaction and development of vascular cognitive impairment and dementia (VCID) in the …
Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation …
Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …
novel interventional strategies for treatment and prevention of age-related vascular …
Treatment with the poly (ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and …
Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling
(NVC) plays an important role in the maintenance of healthy cognitive function. Strong …
(NVC) plays an important role in the maintenance of healthy cognitive function. Strong …
Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia
P Balasubramanian, J DelFavero, A Ungvari… - Ageing research …, 2020 - Elsevier
Aging is the most significant risk factor for vascular cognitive impairment (VCI), and the
number of individuals affected by VCI is expected to exponentially increase in the upcoming …
number of individuals affected by VCI is expected to exponentially increase in the upcoming …
Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice
A Csiszar, A Yabluchanskiy, A Ungvari, Z Ungvari… - Geroscience, 2019 - Springer
Moment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via the
homeostatic mechanism known as neurovascular coupling (NVC) has an essential role in …
homeostatic mechanism known as neurovascular coupling (NVC) has an essential role in …
[HTML][HTML] Protective effects of PACAP in peripheral organs
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …
[HTML][HTML] Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy
B Sonkodi, MD Resch, T Hortobágyi - Journal of Molecular Neuroscience, 2022 - Springer
Dry eye disease (DED) is a multifactorial disorder with recognized pathology, but not entirely
known pathomechanism. It is suggested to represent a continuum with neuropathic corneal …
known pathomechanism. It is suggested to represent a continuum with neuropathic corneal …
Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice
Cognitive impairment is one of the most common co-occurring chronic conditions among
elderly heart failure patients (incidence: up to~ 80%); however, the underlying mechanisms …
elderly heart failure patients (incidence: up to~ 80%); however, the underlying mechanisms …