An insight into GPCR and G-proteins as cancer drivers
PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …
receptors known to play a crucial role in various physiological functions, including tumor …
Chemotaxis in cancer
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …
essential component of tumour dissemination during progression and metastasis. This …
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers
N Arang, JS Gutkind - FEBS letters, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …
G protein-coupled receptors: novel targets for drug discovery in cancer
R Lappano, M Maggiolini - Nature reviews Drug discovery, 2011 - nature.com
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …
proteins that have a pivotal role in many physiological functions and in multiple diseases …
RGS12 represses oral cancer via the phosphorylation and SUMOylation of PTEN
C Fu, G Yuan, ST Yang, D Zhang… - Journal of dental …, 2021 - journals.sagepub.com
Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer
characterized by aggressive local invasion and metastasis. The pathogenesis of OSCC is …
characterized by aggressive local invasion and metastasis. The pathogenesis of OSCC is …
RGS6 suppresses TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4
Z Wang, J Chen, S Wang, Z Sun, Z Lei, HT Zhang… - Cell Death & …, 2022 - nature.com
Regulator of G-protein signaling 6 (RGS6) is a newly discovered tumor suppressor that has
been shown to be protective in development of various cancers such as breast cancer and …
been shown to be protective in development of various cancers such as breast cancer and …
Heterotrimeric Gq proteins as therapeutic targets?
E Kostenis, EM Pfeil, S Annala - Journal of Biological Chemistry, 2020 - ASBMB
Heterotrimeric G proteins are the core upstream elements that transduce and amplify the
cellular signals from G protein–coupled receptors (GPCRs) to intracellular effectors. GPCRs …
cellular signals from G protein–coupled receptors (GPCRs) to intracellular effectors. GPCRs …
Fatty acid metabolism is related to the immune microenvironment changes of gastric cancer and RGS2 is a new tumor biomarker
S Yang, B Sun, W Li, H Yang, N Li, X Zhang - Frontiers in Immunology, 2022 - frontiersin.org
Background Alterations in lipid metabolism promote tumor progression. However, the role of
lipid metabolism in the occurrence and development of gastric cancer have not been fully …
lipid metabolism in the occurrence and development of gastric cancer have not been fully …
Introduction: G protein-coupled receptors and RGS proteins
Here, we provide an overview of the role of regulator of G protein-signaling (RGS) proteins
in signaling by G protein-coupled receptors (GPCRs), the latter of which represent the …
in signaling by G protein-coupled receptors (GPCRs), the latter of which represent the …
Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance
RGS10 is an important regulator of cell survival and chemoresistance in ovarian cancer. We
recently showed that RGS10 transcript expression is suppressed during acquired …
recently showed that RGS10 transcript expression is suppressed during acquired …