X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …

In eukaryotes transcriptional regulation often involves multiple long-range elements and is
influenced by the genomic environment. A prime example of this concerns the mouse X …

Deregulated expression of COX-2 has been causally linked to development, progression,
and outcome of several types of human cancer. We describe a novel fundamental level of …

In mammals, dosage compensation between XX and XY individuals occurs through X
chromosome inactivation (XCI). The noncoding Xist RNA is expressed and initiates XCI only …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

CTCF is a master regulator that plays important roles in genome architecture and gene
expression. How CTCF is recruited in a locus-specific manner is not fully understood …

A growing body of evidence suggests that insulators have a primary role in orchestrating the
topological arrangement of higher-order chromatin architecture. Insulator-mediated long …

X-chromosome inactivation (XCI) is a developmentally associated process that evolved in
mammals to enable gene dosage compensation between XX and XY individuals. In …

Extensive 3D folding is required to package a genome into the tiny nuclear space, and this
packaging must be compatible with proper gene expression. Thus, in the well-hierarchized …