In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Medical pain management is in crisis; from the pervasiveness of pain to inadequate pain
treatment, from the escalation of prescription opioids to an epidemic in addiction, diversion …

Chinese translation Background: Among former prisoners, a high rate of death has been
documented in the early postrelease period, particularly from drug-related causes. Little is …

The relationships between the initial opioid prescription characteristics and pain etiology
with the probability of opioid discontinuation were explored in this retrospective cohort study …

OBJECTIVE: To report the prevalence of prescription opioid use and evaluate the trends in a
large cohort of Medicaid-enrolled pregnant women. METHODS: A cohort of pregnancies …

Background: Deaths due to prescription opioid overdoses have increased dramatically. High-
quality guidelines could help clinicians mitigate risks associated with opioid therapy …

Background Overdose deaths have increased steadily over the past decade. This report
describes drug-related deaths and emergency department (ED) visits among women …

Chronic pain is one of the most common health conditions among older adults (> 65 years)
and is associated with significant disability. Chronic pain in the older adult reduces mobility …