Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation

B Long, BM Carius, S Chavez, SY Liang… - The American journal of …, 2022 - Elsevier
Introduction Coronavirus disease of 2019 (COVID-19) has resulted in millions of cases
worldwide. As the pandemic has progressed, the understanding of this disease has evolved …

Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and …

BM Henry, J Vikse, S Benoit, EJ Favaloro, G Lippi - Clinica chimica acta, 2020 - Elsevier
Early clinical evidence suggests that severe cases of coronavirus disease 2019 (COVID-19),
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are …

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

MR Garvin, C Alvarez, JI Miller, ET Prates, AM Walker… - elife, 2020 - elifesciences.org
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …

COVID-19: attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism

L Wenzhong, L Hualan - 2020 - chemrxiv.org
The novel coronavirus pneumonia is a contagious acute respiratory disease caused by the
SARS-COV-2 coronavirus. The pathogenic mechanism of the novel coronavirus is unknown …

Role of vitamins and minerals as immunity boosters in COVID-19

P Kumar, M Kumar, O Bedi, M Gupta, S Kumar… - …, 2021 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) known as coronavirus
disease (COVID-19), emerged in Wuhan, China, in December 2019. On March 11, 2020, it …

Natural history of COVID-19 and therapeutic options

P Gautret, M Million, PA Jarrot… - Expert review of …, 2020 - Taylor & Francis
Introduction: COVID-19 presents benign forms in young patients who frequently present with
anosmia. Infants are rarely infected, while severe forms occur in patients over 65 years of …

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

C Sun, C Xie, GL Bu, LY Zhong, MS Zeng - Signal Transduction and …, 2022 - nature.com
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

Silent hypoxia in COVID-19: pathomechanism and possible management strategy

A Rahman, T Tabassum, Y Araf, A Al Nahid… - Molecular biology …, 2021 - Springer
The novel coronavirus disease 2019 (COVID-19) has become a severe health issue,
especially to the patients who develop silent hypoxia condition after SARS-CoV-2 infection …

Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

JT Jan, TJR Cheng, YP Juang, HH Ma… - Proceedings of the …, 2021 - National Acad Sciences
The outbreak of COVID-19 caused by SARS-CoV-2 has resulted in more than 50 million
confirmed cases and over 1 million deaths worldwide as of November 2020. Currently, there …

Pathogenesis, clinical manifestations and complications of COVID-19

E Kordzadeh-Kermani, H Khalili… - Future microbiology, 2020 - Taylor & Francis
Aim: Despite the similarities in the pathogenesis of the beta coronaviruses, the precise
infective mechanisms of SARS-CoV-2 remain unclear. Objective: In this review, we aim to …