Genomic instability and inflammation are intricately connected hallmark features of cancer.
DNA repair defects due to BRCA1/2 mutation instigate immune signaling through the …

Migration through micron-size constrictions has been seen to rupture the nucleus, release
nuclear-localized GFP, and cause localized accumulations of ectopic 53BP1—a DNA repair …

Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to
assess putative driver mutations identified by large-scale sequencing of human cancer …

Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1
C61G mutation in the BRCA1 RING domain is a common pathogenic missense variant …

Breast and ovarian cancer are among the most common malignancies diagnosed in women
worldwide. Together, they account for the majority of cancer-related deaths in women. These …

Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women
to breast cancer. BRCA1 plays an important role in DNA double-strand break (DSB) repair …

Introduction BRCA-mutated breast cancer cells lack the DNA-repair mechanism
homologous recombination that is required for error-free DNA double-strand break (DSB) …

BRCA1-mutated breast cancer is primarily driven by DNA copy-number alterations (CNAs)
containing large numbers of candidate driver genes. Validation of these candidates requires …

Triple-negative breast cancers (TNBC) are genetically characterized by aberrations in TP53
and a low rate of activating point mutations in common oncogenes, rendering it challenging …

Human breast cancer susceptibility gene, BRCA2, encodes a 3418-amino acid protein that
is essential for maintaining genomic integrity. Among the proteins that physically interact …