Glutamine is an abundant and versatile nutrient that participates in energy formation, redox
homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Several decades of research have sought to characterize tumor cell metabolism in the hope
that tumor-specific activities can be exploited to treat cancer. Having originated from …

Rho GTPases impact a number of activities important for oncogenesis. We describe a small
molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in …

The tumor microenvironment can be hypoxic, acidic, and deficient in nutrients, thus causing
the metabolism of tumor cells as well as the neighboring stromal cells to be remodelled to …

Most cancer cells predominantly produce energy by glycolysis rather than oxidative
phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate …

In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1,
the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea …

Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1,
are coordinately elevated in a wide spectrum of primary human cancers, suggesting that …

Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …