Genotoxic and cytotoxic effects of aflatoxin on the reproductive system: Focus on cell cycle dynamics and apoptosis in testicular tissue

C Jalili, B Amiri, S Kakebaraie, F Jalili, TZ Nasta - Toxicology, 2024 - Elsevier
Aflatoxins (AFs) are inevitable environmental contaminants that are detrimental to human
and animal health. AFs interfere with metabolic processes, metabolizing into different …

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

H Rasouli, FD Nayeri, R Khodarahmi - Frontiers in nutrition, 2022 - frontiersin.org
The future GCC-connected environmental risk factors expedited the progression of nCDs.
Indeed, the emergence of AFs is becoming a global food security concern. AFs are lethal …

Dietary aflatoxin B1 and antimalarial—a lumefantrine/artesunate—therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms

SE Owumi, AO Umez, U Arunsi, CE Irozuru - Scientific Reports, 2023 - nature.com
We investigated the impact of Coartem™(COA) and aflatoxin B1 (AFB1) on rats'
hypothalamus, epididymis, and testis. Male rats were randomly grouped (n= 5 rats) and …

Antioxidant, anti-inflammatory, and anti-apoptotic effects of genkwanin against aflatoxin B1-induced testicular toxicity

MU Ijaz, A Ishtiaq, A Tahir, MA Alvi, A Rafique… - Toxicology and Applied …, 2023 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) is the most hazardous aflatoxin that causes significant
damage to the male reproductive system. Genkwanin (GNK) is a bioactive flavonoid that …

Aflatoxin B1 exposure triggers inflammation and premature skin aging via ERMCS/Ca2+/ROS signaling cascade

D Wu, Y Wu, M Zhang, H Lan - International Immunopharmacology, 2023 - Elsevier
Abstract Aflatoxin B1 (AFB1) is a recognized hazard environmental contaminant mainly
found in cereal and fruits. The toxicity of AFB1 exposure to various organs has been …

[HTML][HTML] Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells

S Han, H Zhang, X Liu, F Wen, B Li, Z Bie, H Qiu… - … and Environmental Safety, 2023 - Elsevier
The deleterious effects of aflatoxins, especially aflatoxin B1 (AFB1) which are widespread at
all stages of food production, on the reproductive system have been widely reported in …

Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B1-induced dysregulation of male rat hypothalamic-reproductive axis

SE Owumi, MT Otunla, UO Arunsi… - … Biology and Medicine, 2022 - journals.sagepub.com
We examined the protective effect of the apigeninidin (API)-enriched fraction from Sorghum
bicolor sheaths extracts (SBE-05, SBE-06, and SBE-07) against aflatoxin B1 (AFB1)-induced …

Bacillus licheniformis ameliorates Aflatoxin B1-induced testicular damage by improving the gut-metabolism-testis axis

FL Zhang, HH Ma, PY Dong, YMC Yan, Y Chen… - Journal of Hazardous …, 2024 - Elsevier
Abstract Global aflatoxin B1 (AFB1) contamination is inevitable, and it can significantly
damage testicular development. However, the current mechanism is confusing. Here, by …

Network toxicology and molecular docking for the toxicity analysis of food contaminants: A case of Aflatoxin B1

ZY Chu, XJ Zi - Food and Chemical Toxicology, 2024 - Elsevier
The present study aims to promote network toxicology and molecular docking strategies for
the efficient evaluation of the toxicity of food contaminants. With the example of liver injury …

Camel milk or silymarin could improve the negative effects that experimentally produced by aflatoxin B1 on rat's male reproductive system

NH Hassaneen, SA Hemeda, AF El Nahas… - BMC Veterinary …, 2024 - Springer
Background Camel milk and silymarin have many different beneficial effects on several
animal species. Meanwhile, Aflatoxins are mycotoxins with extraordinary potency that pose …