The stereocontrolled construction of chiral carbo-and heterocycles is a topic of paramount
importance in modern organic synthesis, driven by the predominance of chiral mono-and …

Enantioselective synthesis with small-molecule chiral hydrogen-bond donors has emerged
as a frontier of research in the field of asymmetric catalysis. Organic chemists have …

Hydrogen bonding is responsible for the structure of much of the world around us. The
unusual and complex properties of bulk water, the ability of proteins to fold into stable three …

Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

Chiral phosphoric acids and derivatives have attracted considerable attention as a powerful
tool in asymmetric catalysis. Various enantioselective reactions have been developed by …

Over the last decade the potential for N, N‐dialkyl (thio) urea derivatives to serve as active
metal‐free organocatalysts for a wide range of synthetically useful reactions susceptible to …

Hydrogen bond catalysis and Brønsted acid catalysis are rapidly growing areas in
organocatalysis. A number of chiral acid catalysts has been developed recently. Recent …

The first enantioselective organocatalytic reductive amination reaction has been
accomplished. The development of a new chiral phosphoric acid catalyst has provided a …

Binaphthol-derived monophosphoric acids have been designed as novel chiral Brønsted-
acid catalysts. The chiral phosphoric acids thus developed function as efficient …

We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an
1, 2-amino alcohol in expectation of their synchronous activation of a nucleophile and an …