Effects of exercise on anxiety and depression disorders: review of meta-analyses and neurobiological mechanisms

M Wegner, I Helmich, S Machado… - CNS & Neurological …, 2014 - ingentaconnect.com
Anxiety and depression are the most frequently diagnosed psychological diseases showing
a high co-morbidity. They have a severe impact on the lives of the persons concerned. Many …

Molecular mechanisms underlying cardiac adaptation to exercise

RB Vega, JP Konhilas, DP Kelly, LA Leinwand - Cell metabolism, 2017 - cell.com
Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

Long-term exercise from adolescence to adulthood reduces anxiety-and depression-like behaviors following maternal immune activation in offspring

S Rahimi, M Peeri, MA Azarbayjani, L Anoosheh… - Physiology & …, 2020 - Elsevier
Maternal immune activation is an environmental risk factor for the development of
neuropsychiatric disorders such as anxiety and depression later in life. There is an urgent …

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

AH Nagahara, MH Tuszynski - Nature reviews Drug discovery, 2011 - nature.com
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …

The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels

C Chen, S Nakagawa, Y An, K Ito, Y Kitaichi… - Frontiers in …, 2017 - Elsevier
Exercise is known to have beneficial effects on cognition, mood, and the brain. However,
exercise also activates the hypothalamic–pituitary–adrenal axis and increases levels of the …

A runner's high depends on cannabinoid receptors in mice

J Fuss, J Steinle, L Bindila, MK Auer… - Proceedings of the …, 2015 - National Acad Sciences
Exercise is rewarding, and long-distance runners have described a runner's high as a
sudden pleasant feeling of euphoria, anxiolysis, sedation, and analgesia. A popular belief …

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

SY Yau, A Li, RLC Hoo, YP Ching… - Proceedings of the …, 2014 - National Acad Sciences
Adiponectin (ADN) is an adipocyte-secreted protein with insulin-sensitizing, antidiabetic,
antiinflammatory, and antiatherogenic properties. Evidence is also accumulating that ADN …

Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data

KA Ashcraft, RM Peace, AS Betof, MW Dewhirst… - Cancer research, 2016 - AACR
A major objective of the emerging field of exercise–oncology research is to determine the
efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence …

The muscle-brain axis and neurodegenerative diseases: the key role of mitochondria in exercise-induced neuroprotection

J Burtscher, GP Millet, N Place, B Kayser… - International Journal of …, 2021 - mdpi.com
Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

Effects of voluntary and involuntary exercise on cognitive functions, and VEGF and BDNF levels in adolescent rats

N Uysal, M Kiray, AR Sisman, UM Camsari… - Biotechnic & …, 2015 - Taylor & Francis
Regular treadmill running during adolescence improves learning and memory in rats.
During adolescence, the baseline level of stress is thought to be greater than during other …