Melatonin is a small, highly conserved indole with numerous receptor-mediated and
receptor-independent actions. Receptor-dependent functions include circadian rhythm …

Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

BACKGROUND Research within the last decade has shown melatonin to have previously-
unsuspected beneficial actions on the peripheral reproductive organs. Likewise, numerous …

Angiogenesis is an essential process involved in various physiological, including
placentation, and pathological, including cancer and endometriosis, processes. Melatonin …

The present review discusses recent work on melatonin-mediated circadian regulation, the
metabolic and molecular signaling mechanisms that are involved in human breast cancer …

Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …

Melatonin has a wide variety of beneficial actions at the level of the gonads and their
adnexa. Some actions are mediated via its classic membrane melatonin receptors while …

Introduction: Compelling evidence has highlighted the complex pleiotropic functions elicited
by the melatonin in cancer cells. Melatonin behaves as a 'smart killer', ie, modulating anti …

As neovascularization is essential for tumor growth and metastasis, controlling angiogenesis
is a promising tactic in limiting cancer progression. Melatonin has been studied for their …

Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal
gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and …