In humans, the glutathione S-transferases (GST) protein family is composed of seven
members that present remarkable structural similarity and some degree of overlapping …

Cancer is a major public health problem and one of the leading contributors to the global
disease burden. The high cost of development of new drugs and the increasingly severe …

Antidepressants refer to psychotropic drugs which are used to treat mental illness with
prominent emotional depression symptoms. It was reported that antidepressants had …

Background. Oxaliplatin (L‐OHP) resistance is a major obstacle to the effective treatment of
colorectal cancer. The resistance mechanism (s) of colorectal tumors to L‐OHP may be …

Background Chemoresistance is one of the major obstacles for tumor treatment. Circular
RNAs (circRNAs) have been confirmed to play vital roles in chemoresistance of cancer …

The survival, functioning and proliferation of mammalian cells are highly dependent on the
cellular response and adaptation to changes in their redox environment. Cancer cells often …

AIM To reveal the insight mechanism of liver metastasis in uveal melanoma, we investigated
cell functions of microRNA-21 in three different uveal melanoma cell lines and analyze the …

It has been reported that the expression of zinc finger protein 139 (ZNF139) and microRNA-
185 (miR-185) were associated with proliferation, drug resistance of gastric cancer (GC) …

Background Chemoresistance is a major barrier limiting the therapeutic efficacy of late stage
non‐small cell lung cancer (NSCLC). In this study, we sought to use two‐dimensional …

Glutathione reductase (GR) is a homodimeric enzyme playing an important role in the
regeneration of the central antioxidant molecule reduced glutathione (GSH) from oxidized …