Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and
muscle function in the lower limbs. A skeletal muscle myopathy characterized by …

Annually, peripheral arterial disease is estimated to cost over USD 21 billion and diabetic
foot disease an estimated at USD 9–13 billion. Mirabegron is a TGA-approved beta-3 …

Laser speckle contrast imaging (LSCI) is a powerful tool to monitor blood flow distribution
and has been widely used in studies of microcirculation, both for animal and clinical …

Peripheral artery disease (PAD) is characterized by the accumulation of atherosclerotic
plaques in the lower extremity conduit arteries, which impairs blood flow and walking …

Objectives Current chronic limb threatening ischemia (CLTI) diagnostics require expensive
equipment, using ionizing radiation or contrast agents, or summative surrogate methods …

Microvascular disease plays a critical role in systemic end-organ dysfunction, and treatment
of microvascular pathologies may greatly reduce cardiovascular morbidity and mortality. The …

Background Numerous epidemiological studies have shown that hypertriglyceridemia is a
significant risk factor for cardiovascular diseases (CVD). However, large clinical studies on …

Background: Patients with peripheral artery disease (PAD) often experience intermittent
claudication. It is manifested by pain typically seen in the distal part of the legs during …

Changes in the microcirculation of the skin are a frequently observed accompanying
phenomenon of many diseases, far beyond the spectrum of dermatological diseases. Not all …