The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

The generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells
(iPSCs) is an active and promising area of research; however, generating engraftable HSCs …

In vitro cultured blood cells for transfusion purposes provide a safe alternative to donor
blood, particularly for patients who require recurrent transfusions, and can be used as …

During development, erythroid cells are produced through at least 2 distinct hematopoietic
waves (primitive and definitive), generating erythroblasts with different functional …

Red blood cell (RBC) transfusion is a lifesaving medical procedure that can treat patients
with anemia and hemoglobin disorders. However, the shortage of blood supply and risks of …

Red blood cells (RBCs)(erythrocytes) are the simplest primary human cells, lacking nuclei
and major organelles and instead employing about a thousand proteins to dynamically …

The discovery of iPSCs has led to the ex vivo production of differentiated cells for
regenerative medicine. In the case of transfusion products, the derivation of platelets from …

Differentiation of stem and progenitor cells is a highly regulated process that involves the
coordinated action of multiple layers of regulation. Here we show how the post …

Background: Sickle cell disease (SCD) is a highly prevalent genetic disease caused by a
point mutation in the HBB gene, which can lead to chronic hemolytic anemia and vaso …

Autophagy is an intracellular degradation process that is essential for cellular survival, tissue
homeostasis, and human health. The housekeeping functions of autophagy in mediating the …