Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester
the element gives ferritin the dual functions of iron detoxification and iron reserve. The …

S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain
of cysteine, has emerged as an important mechanism for dynamic, post-translational …

Iron is vital for almost all living organisms by participating in a wide variety of metabolic
processes, including oxygen transport, DNA synthesis, and electron transport. However, iron …

Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe (II) iron across
the brush border membrane and culminates in transfer of the metal across the basolateral …

As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in
biology and medicine. At the cellular level, the basic molecular framework for the regulation …

Virtually all living cells possess an absolute re-Ž. quirement for iron Fe, and it has been
suggested that reactions catalyzed by Fe may have constituted a wx first step in the origin of …

▪ Abstract Mammalian iron homeostasis is maintained through the concerted action of
sensory and regulatory networks that modulate the expression of proteins of iron metabolism …

Parkinson's disease is characterized by a loss of dopaminergic neurons in the
mesencephalon. Although the mechanism of this neuronal loss is still unknown, oxidative …

Sixty years ago Carl Martius (1906-1993), then “Wissenschaftlicher Assistent” to Franz
Knoop at the Biochemical Institute of the University of Tubingen, did an experiment, crucial …