Obesity is an independent risk factor for development and progression of renal damage.
Although the current therapies aimed at slowing progressive renal damage include …

Nuclear receptors have a broad spectrum of biological functions in normal physiology and in
the pathology of various diseases, including glomerular disease. The primary therapies for …

Chronic kidney disease (CKD) occurs in all age groups, including children. Regardless of
the underlying cause, CKD is characterized by progressive scarring that ultimately affects all …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists not only improve metabolic
abnormalities of diabetes and consequent diabetic nephropathy, but they also protect …

Loss of podocytes by apoptosis characterizes the early stages of diabetic nephropathy. To
examine its mechanism we studied glomeruli and podocytes isolated from db/db mice with …

The introduction of corticosteroids more than 50 years ago dramatically improved the
prognosis of children with nephrotic syndrome. Corticosteroids remain the standard initial …

The kidney has extraordinary metabolic demands to sustain the active transport of solutes
that is critical to renal filtration and clearance. Mitochondrial health is vital to meet those …

Aldosterone (Aldo) causes podocyte damage by an unknown mechanism. We examined the
role of mitochondrial dysfunction (MtD) in Aldo-treated podocytes in vitro and in vivo …

Mitochondrial dysfunction is important in the pathogenesis of various kidney diseases and
the mitochondria potentially serve as therapeutic targets necessitating further investigation …

Podocyte injury and loss contribute to progressive glomerulosclerosis. Peroxisome
proliferator-activated receptor-γ (PPAR-γ) is a nuclear hormone receptor, which we have …