In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core
made from the viral capsid (CA) protein. The CA protein and the structure into which it …

After invasion of a susceptible target cell, HIV-1 completes the early phase of its life cycle
upon integration of reverse-transcribed viral DNA into host chromatin. The viral capsid, a …

After fusion, HIV delivers its conical capsid into the cytoplasm. To release the contained
reverse-transcribing viral genome, the capsid must disassemble in a process termed …

RASGRP1 is an important guanine nucleotide exchange factor and activator of the RAS-
MAPK pathway following T cell antigen receptor (TCR) signaling. The consequences of …

Numerous viruses, including HIV-1, exploit the microtubule network to traffic toward the
nucleus during infection. Although numerous studies have observed a role for the minus …

Human immunodeficiency virus type 1 (HIV-1) infection depends on efficient
intracytoplasmic transport of the incoming viral core to the target cell nucleus. Evidence …

Microtubules (MTs) form a filamentous array that provide both structural support and a
coordinated system for the movement and organization of macromolecular cargos within the …

The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus
infection has been known for decades. However, most of the studies characterizing this …

Membraneless biomolecular condensates (BMCs) contribute to the replication of a growing
number of viruses but remain to be functionally characterized. Previously, we demonstrated …

Targeted therapies such as venetoclax (VEN)(Bcl-2 inhibitor) have revolutionized the
treatment of chronic lymphocytic leukemia (CLL). We previously reported that persister CLL …