Sexual dimorphism in colon cancer

M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Obesity: A perfect storm for carcinogenesis

BHL Harris, VM Macaulay, DA Harris… - Cancer and Metastasis …, 2022 - Springer
Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

[HTML][HTML] New insights into the functions of progesterone receptor (PR) isoforms and progesterone signaling

JM Azeez, TR Susmi, V Remadevi… - American journal of …, 2021 - ncbi.nlm.nih.gov
Progesterone, the ovarian steroid hormone, regulates a plentitude of biological processes in
tissues ranging from the brain to bones. Recognizing the role of progesterone and its …

[HTML][HTML] Sex difference of colon adenoma pathway and colorectal carcinogenesis

Y Choi, N Kim - The World Journal of Men's Health, 2024 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …

[HTML][HTML] Enhanced anti-cancer effects of oestrogen and progesterone co-therapy against colorectal cancer in males

AA Mahbub, A Aslam, ME Elzubier… - Frontiers in …, 2022 - frontiersin.org
Although ovarian sex steroids could have protective roles against colorectal cancer (CRC) in
women, little is currently known about their potential anti-tumorigenic effects in men. Hence …

New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression

J Kamińska, OM Koper-Lenkiewicz… - Cancers, 2023 - mdpi.com
Simple Summary Progesterone (P4) via PGRMC1/NENF may stimulate the proliferation and
invasion of colorectal cancer DLD-1 and HT-29 cells. PGRMC1 inhibition abolishes the …

Synbiotic Combination of Djulis (Chenopodium formosanum) and Lactobacillus acidophilus Inhibits Colon Carcinogenesis in Rats

CW Lee, HJ Chen, YH Chien, SM Hsia, JH Chen… - Nutrients, 2019 - mdpi.com
Djulis is a functional grain containing prebiotic dietary fiber, which has an anti-cancer
potential. This study examined the preventive effect of djulis alone or in combination with …

Design of pH-responsive polymeric nanocarrier for targeted delivery of pyrogallol with enhanced antitumor potential in colon cancer

GA Mahmoud, HE Ali, RR Radwan - Archives of Biochemistry and …, 2022 - Elsevier
Purpose To synthesize a polymeric pH-sensitive nanocarrier for the delivery of pyrogallol
and investigate the anti-tumor activity of pyrogallol-loaded polymeric nanogel against colon …

Delineating the role of nuclear receptors in colorectal cancer, a focused review

MK Manickasamy, S Jayaprakash, S Girisa, A Kumar… - Discover Oncology, 2024 - Springer
Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally,
causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to …

[HTML][HTML] Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness

B Refaat, A Aslam, S Idris, AH Almalki… - Frontiers in …, 2023 - frontiersin.org
Background Although estrogen (ERα/ERβ), progesterone (PGR), and androgen (AR)
receptors are pathologically altered in colorectal cancer (CRC), their simultaneous …