EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
D Pradella, C Naro, C Sette, C Ghigna - Molecular cancer, 2017 - Springer
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
Chromatin and epigenetic rearrangements in embryonic stem cell fate transitions
L Sun, X Fu, G Ma, AP Hutchins - Frontiers in cell and developmental …, 2021 - frontiersin.org
A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …
the somatic genome is reprogrammed for a new round of organismal development …
Chromatin accessibility dynamics during iPSC reprogramming
Cell-fate decisions remain poorly understood at the chromatin level. Here, we map
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …
Genomic and proteomic resolution of heterochromatin and its restriction of alternate fate genes
Heterochromatin is integral to cell identity maintenance by impeding the activation of genes
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …
Phase separation of BuGZ regulates gut regeneration and aging through interaction with m6A regulators
Q Zhang, K Deng, M Liu, S Yang, W Xu, T Feng… - Nature …, 2023 - nature.com
Exploring the role of phase separation in intracellular compartment formation is an active
area of research. However, the associations of phase separation with intestinal stem cell …
area of research. However, the associations of phase separation with intestinal stem cell …
Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing
QR Xing, C El Farran, P Gautam, YS Chuah… - Science …, 2020 - science.org
Cellular reprogramming suffers from low efficiency especially for the human cells. To
deconstruct the heterogeneity and unravel the mechanisms for successful reprogramming …
deconstruct the heterogeneity and unravel the mechanisms for successful reprogramming …
Alternative splicing of HSPA12A pre‐RNA by SRSF11 contributes to metastasis potential of colorectal cancer
YJ Pan, FC Huo, MJ Kang, BW Liu… - Clinical and …, 2022 - Wiley Online Library
Background Dysregulation of alternative splicing (AS) induced by serine/arginine‐rich
proteins has recently been linked to cancer metastasis. Nonetheless, as a member of the …
proteins has recently been linked to cancer metastasis. Nonetheless, as a member of the …
Global H3. 3 dynamic deposition defines its bimodal role in cell fate transition
HT Fang, CA El Farran, QR Xing, LF Zhang, H Li… - Nature …, 2018 - nature.com
H3. 3 is a histone variant, which is deposited on genebodies and regulatory elements, by
Hira, marking active transcription. Moreover, H3. 3 is deposited on heterochromatin by …
Hira, marking active transcription. Moreover, H3. 3 is deposited on heterochromatin by …
Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia
RL Mayer, JD Schwarzmeier, MC Gerner… - Molecular & Cellular …, 2018 - ASBMB
B cell chronic lymphocytic leukemia (B-CLL), the most common type of leukemia in adults, is
still essentially incurable despite the development of novel therapeutic strategies. This …
still essentially incurable despite the development of novel therapeutic strategies. This …
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells
A rare sub-population of mouse embryonic stem cells (mESCs), the 2-cell-like cell, is defined
by the expression of MERVL and 2-cell-stage-specific transcript (2C transcript). Here, we …
by the expression of MERVL and 2-cell-stage-specific transcript (2C transcript). Here, we …