Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …

A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …

Cell-fate decisions remain poorly understood at the chromatin level. Here, we map
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …

Heterochromatin is integral to cell identity maintenance by impeding the activation of genes
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …

Exploring the role of phase separation in intracellular compartment formation is an active
area of research. However, the associations of phase separation with intestinal stem cell …

Cellular reprogramming suffers from low efficiency especially for the human cells. To
deconstruct the heterogeneity and unravel the mechanisms for successful reprogramming …

Background Dysregulation of alternative splicing (AS) induced by serine/arginine‐rich
proteins has recently been linked to cancer metastasis. Nonetheless, as a member of the …

H3. 3 is a histone variant, which is deposited on genebodies and regulatory elements, by
Hira, marking active transcription. Moreover, H3. 3 is deposited on heterochromatin by …

B cell chronic lymphocytic leukemia (B-CLL), the most common type of leukemia in adults, is
still essentially incurable despite the development of novel therapeutic strategies. This …

A rare sub-population of mouse embryonic stem cells (mESCs), the 2-cell-like cell, is defined
by the expression of MERVL and 2-cell-stage-specific transcript (2C transcript). Here, we …