Functional amyloids

D Otzen, R Riek - Cold Spring Harbor perspectives in …, 2019 - cshperspectives.cshlp.org
When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

Giving structure to the biofilm matrix: an overview of individual strategies and emerging common themes

L Hobley, C Harkins, CE MacPhee… - FEMS microbiology …, 2015 - academic.oup.com
Biofilms are communities of microbial cells that underpin diverse processes including
sewage bioremediation, plant growth promotion, chronic infections and industrial biofouling …

Programmable and printable Bacillus subtilis biofilms as engineered living materials

J Huang, S Liu, C Zhang, X Wang, J Pu, F Ba… - Nature chemical …, 2019 - nature.com
Bacterial biofilms can be programmed to produce living materials with self-healing and
evolvable functionalities. However, the wider use of artificial biofilms has been hindered by …

[HTML][HTML] Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms

J Böhning, M Ghrayeb, C Pedebos, DK Abbas… - Nature …, 2022 - nature.com
Many bacteria in nature exist in multicellular communities termed biofilms, where cells are
embedded in an extracellular matrix that provides rigidity to the biofilm and protects cells …

[HTML][HTML] The role of functional amyloids in bacterial virulence

N Van Gerven, SE Van der Verren, DM Reiter… - Journal of molecular …, 2018 - Elsevier
Amyloid fibrils are best known as a product of human and animal protein misfolding
disorders, where amyloid formation is associated with cytotoxicity and disease. It is now …

Biofilm formation by Bacillus subtilis: new insights into regulatory strategies and assembly mechanisms

LS Cairns, L Hobley… - Molecular microbiology, 2014 - Wiley Online Library
Biofilm formation is a social behaviour that generates favourable conditions for sustained
survival in the natural environment. For the Gram‐positive bacterium B acillus subtilis the …

[HTML][HTML] Functional amyloid and other protein fibers in the biofilm matrix

E Erskine, CE MacPhee, NR Stanley-Wall - Journal of Molecular Biology, 2018 - Elsevier
Biofilms are ubiquitous in the natural and man-made environment. They are defined as
microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing …

Structural changes of TasA in biofilm formation of Bacillus subtilis

A Diehl, Y Roske, L Ball… - Proceedings of the …, 2018 - National Acad Sciences
Microorganisms form surface-attached communities, termed biofilms, which can serve as
protection against host immune reactions or antibiotics. Bacillus subtilis biofilms contain …

The matrix reloaded: how sensing the extracellular matrix synchronizes bacterial communities

N Steinberg, I Kolodkin-Gal - Journal of bacteriology, 2015 - Am Soc Microbiol
In response to chemical communication, bacterial cells often organize themselves into
complex multicellular communities that carry out specialized tasks. These communities are …

Multiscale X-ray study of Bacillus subtilis biofilms reveals interlinked structural hierarchy and elemental heterogeneity

DN Azulay, O Spaeker, M Ghrayeb… - Proceedings of the …, 2022 - National Acad Sciences
Biofilms are multicellular microbial communities that encase themselves in an extracellular
matrix (ECM) of secreted biopolymers and attach to surfaces and interfaces. Bacterial …