Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …
Exploration of 1, 2, 3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase
Abstract A novel series of 1, 2, 3-triazole benzenesulfonamide substituted 1, 3-
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
Discovery of novel benzenesulfonamides incorporating 1, 2, 3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors
Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif
The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and h CAIs) remain
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions
In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a–l) was
synthesized using the tail-approach method. The compounds were characterized using IR …
synthesized using the tail-approach method. The compounds were characterized using IR …
Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel …
Some metabolic enzyme inhibitors can be used in the treatment of many diseases.
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo [2, 1-b][1, 3, 4] thiadiazoles as highly potent acetylcholinesterase and non …
Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors
Carbonic anhydrase (CA) enzymes are involved in many physiological events. These
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …