Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Neurodegenerative diseases are characterized by chronic microglial over-activation and
oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) …

Aging is a multi-factorial process developing through a complex net of interactions between
biological and cellular mechanisms and it involves oxidative stress (OS) as well as protein …

Chronic stress and high levels of glucocorticoids produce functional and structural changes
in brain and especially in the hippocampus, an important limbic system structure that plays a …

Alzheimer disease (AD) is a progressive dementia affecting a large proportion of the aging
population. The histopathological changes in AD include neuronal cell death, formation of …

Oxidative stress has been implicated in various aspects of aging, but the role of oxidative
stress in ovarian aging remains unclear. Our previous studies have shown that the initiation …

Glutathione plays a critical role in many biological processes both directly as a co-factor in
enzymatic reactions and indirectly as the major thiol-disulfide redox buffer in mammalian …