Understanding large scale sequencing datasets through changes to protein folding
D Shorthouse, H Lister, GS Freeman… - Briefings in Functional …, 2024 - academic.oup.com
The expansion of high-quality, low-cost sequencing has created an enormous opportunity to
understand how genetic variants alter cellular behaviour in disease. The high diversity of …
understand how genetic variants alter cellular behaviour in disease. The high diversity of …
[HTML][HTML] Impact of Missense Mutations on Spike Protein Stability and Binding Affinity in the Omicron Variant
The global effort to combat the COVID-19 pandemic faces ongoing uncertainty with the
emergence of Variants of Concern featuring numerous mutations on the Spike (S) protein. In …
emergence of Variants of Concern featuring numerous mutations on the Spike (S) protein. In …
Antiviral drug discovery against pathogens of pandemic concern: Advancements in target site identification and structure-based drug development
KM Padmanabha Das - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
The recent emergence of multiple zoonotic viruses such as Ebola virus and severe acute
respiratory syndrome coronavirus 2 (SARS-Cov-2) have demonstrated that viruses of animal …
respiratory syndrome coronavirus 2 (SARS-Cov-2) have demonstrated that viruses of animal …