Immunopathology of RSV: an updated review

HC Bergeron, RA Tripp - Viruses, 2021 - mdpi.com
RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …

Novel antigens for RSV vaccines

BS Graham, K Modjarrad, JS McLellan - Current opinion in immunology, 2015 - Elsevier
Highlights•There are multiple neutralizing antibody binding sites on F protein and at least
one on G protein.•The most potent neutralizing antibodies recognize sites exclusively on the …

Engineering nanolayered particles for modular drug delivery

S Correa, EC Dreaden, L Gu, PT Hammond - Journal of Controlled Release, 2016 - Elsevier
Abstract Layer-by-layer (LbL) based self-assembly of nanoparticles is an emerging and
powerful method to develop multifunctional and tissue responsive nanomedicines for a …

CX3CR1 is expressed in differentiated human ciliated airway cells and co-localizes with respiratory syncytial virus on cilia in a G protein-dependent manner

KI Jeong, PA Piepenhagen, M Kishko, JM DiNapoli… - PloS one, 2015 - journals.plos.org
Respiratory syncytial virus (RSV) is the principal cause of bronchiolitis in infants and a
significant healthcare problem. The RSV Glycoprotein (G) mediates attachment of the virus …

Biology of infection and disease pathogenesis to guide RSV vaccine development

S Boyoglu-Barnum, T Chirkova… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease
in young children and a substantial contributor to respiratory tract disease throughout life …

Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf

JL McGill, SM Kelly, P Kumar, S Speckhart… - Scientific Reports, 2018 - nature.com
Human respiratory syncytial virus (HRSV) is a leading cause of severe acute lower
respiratory tract infection in infants and children worldwide. Bovine RSV (BRSV) is closely …

Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development

JA Melero, V Mas, JS McLellan - Vaccine, 2017 - Elsevier
Extraordinary progress in the structure and immunobiology of the human respiratory
syncytial virus glycoproteins has been accomplished during the last few years …

Antigenic fingerprinting following primary RSV infection in young children identifies novel antigenic sites and reveals unlinked evolution of human antibody repertoires …

S Fuentes, EM Coyle, J Beeler, H Golding… - PLoS …, 2016 - journals.plos.org
Respiratory Syncytial Virus (RSV) is the major cause of pneumonia among infants. Here we
elucidated the antibody repertoire following primary RSV infection and traced its evolution …

Anti-G protein antibodies targeting the RSV G protein CX3C chemokine region improve the interferon response

HC Bergeron, LM Kauvar… - Therapeutic Advances in …, 2023 - journals.sagepub.com
Background: Respiratory syncytial virus (RSV) is a poor inducer of antiviral interferon (IFN)
responses which result in incomplete immunity and RSV disease. Several RSV proteins …

Respiratory syncytial virus (RSV) G protein vaccines with central conserved domain mutations induce CX3C-CX3CR1 blocking antibodies

HC Bergeron, J Murray, AM Nuñez Castrejon… - Viruses, 2021 - mdpi.com
Respiratory syncytial virus (RSV) infection can cause bronchiolitis, pneumonia, morbidity,
and some mortality, primarily in infants and the elderly, for which no vaccine is available …