Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
JR Hwang, Y Byeon, D Kim, SG Park - Experimental & molecular …, 2020 - nature.com
T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …
Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment
H Harjunpää, M Llort Asens, C Guenther… - Frontiers in …, 2019 - frontiersin.org
The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …
playing a dual role in tumor development. The effector cells of the immune system can …
Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
The cellular and molecular mechanisms underlying tumor cell PD-L1 (tPD-L1) function in
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …
The pathogenesis of Parkinson's disease: a complex interplay between astrocytes, microglia, and T lymphocytes?
AN MacMahon Copas, SF McComish… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), the second most common neurodegenerative disease, is
characterised by the motor symptoms of bradykinesia, rigidity and resting tremor and non …
characterised by the motor symptoms of bradykinesia, rigidity and resting tremor and non …
Inflammation in hypertension
L Xiao, DG Harrison - Canadian Journal of Cardiology, 2020 - Elsevier
For more than 50 years, evidence has accumulated that inflammation contributes to the
pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of …
pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of …
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
A Kendirli, C de la Rosa, KF Lämmle, K Eglseer… - Nature …, 2023 - nature.com
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …
lack a comprehensive understanding of the signaling pathways that regulate this process …
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression
Tumor-derived extracellular vesicles (TEVs) suppress the proliferation and cytotoxicity of
CD8+ T cells, thereby contributing to tumor immune evasion. Here, we report that the …
CD8+ T cells, thereby contributing to tumor immune evasion. Here, we report that the …
The functional crosstalk between myeloid-derived suppressor cells and regulatory T cells within the immunosuppressive tumor microenvironment
Simple Summary Immunotherapy improved the therapeutic landscape for patients with
advanced cancer diseases. However, many patients do not benefit from immunotherapy …
advanced cancer diseases. However, many patients do not benefit from immunotherapy …
Comprehensive phenotyping of T cells using flow cytometry
CM Mousset, W Hobo, R Woestenenk… - Cytometry Part …, 2019 - Wiley Online Library
The T cell compartment can form a powerful defense against extrinsic (eg, pathogens) and
intrinsic danger (eg, malignant cells). At the same time, specific subsets of T cells control this …
intrinsic danger (eg, malignant cells). At the same time, specific subsets of T cells control this …
RhoA as a key regulator of innate and adaptive immunity
M Bros, K Haas, L Moll, S Grabbe - Cells, 2019 - mdpi.com
RhoA is a ubiquitously expressed cytoplasmic protein that belongs to the family of small
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …