Vanilloid (Capsaicin) receptors and mechanisms
A Szallasi, PM Blumberg - Pharmacological reviews, 1999 - ASPET
With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …
Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine
G Appendino, A Szallasi - Life sciences, 1997 - Elsevier
Resiniferatoxin, an ultrapotent capsaicin analog present in the latex of Euphorbia resinifera,
interacts at a specific membrane recognition site (referred to as the vanilloid receptor) …
interacts at a specific membrane recognition site (referred to as the vanilloid receptor) …
Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy
GJ Michael, JV Priestley - Journal of Neuroscience, 1999 - Soc Neuroscience
Sensitivity to the pungent vanilloid, capsaicin, defines a subpopulation of primary sensory
neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor …
neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor …
Molecular determinants of vanilloid sensitivity in TRPV1
NR Gavva, L Klionsky, Y Qu, L Shi, R Tamir… - Journal of biological …, 2004 - ASBMB
Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the
pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia …
pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia …
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia
J Shin, H Cho, SW Hwang, J Jung… - Proceedings of the …, 2002 - National Acad Sciences
The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important
role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We …
role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We …
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist
MJ Gunthorpe, HK Rami, JC Jerman, D Smart… - …, 2004 - Elsevier
Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by
peripheral sensory neurones, which is known to play a key role in the detection of noxious …
peripheral sensory neurones, which is known to play a key role in the detection of noxious …
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1
Z Olah, T Szabo, L Karai, C Hough, RD Fields… - Journal of Biological …, 2001 - ASBMB
The real time dynamics of vanilloid-induced cytotoxicity and the specific deletion of
nociceptive neurons expressing the wild-type vanilloid receptor (VR1) were investigated …
nociceptive neurons expressing the wild-type vanilloid receptor (VR1) were investigated …
[图书][B] TRP ion channel function in sensory transduction and cellular signaling cascades
WB Liedtke - 2006 - taylorfrancis.com
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …
progress made in this area of signaling research has yielded findings that offer the potential …
Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist
P Wahl, C Foged, S Tullin, C Thomsen - Molecular pharmacology, 2001 - ASPET
The highly potent vanilloid receptor (VR) agonist resiniferatoxin has been radiolabeled with
125I, and the pharmacology to the cloned rodent VR, VR1, and the endogenous VR in rat …
125I, and the pharmacology to the cloned rodent VR, VR1, and the endogenous VR in rat …
Characterization of functional vanilloid receptors expressed by mast cells
Capsaicin and its ultrapotent analog resiniferatoxin (RTX) act through specific vanilloid
receptors on sensory neurons. The C-type receptor is coupled to 45Ca uptake, whereas the …
receptors on sensory neurons. The C-type receptor is coupled to 45Ca uptake, whereas the …