With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

Resiniferatoxin, an ultrapotent capsaicin analog present in the latex of Euphorbia resinifera,
interacts at a specific membrane recognition site (referred to as the vanilloid receptor) …

Sensitivity to the pungent vanilloid, capsaicin, defines a subpopulation of primary sensory
neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor …

Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the
pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia …

The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important
role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We …

Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by
peripheral sensory neurones, which is known to play a key role in the detection of noxious …

The real time dynamics of vanilloid-induced cytotoxicity and the specific deletion of
nociceptive neurons expressing the wild-type vanilloid receptor (VR1) were investigated …

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …

The highly potent vanilloid receptor (VR) agonist resiniferatoxin has been radiolabeled with
125I, and the pharmacology to the cloned rodent VR, VR1, and the endogenous VR in rat …

Capsaicin and its ultrapotent analog resiniferatoxin (RTX) act through specific vanilloid
receptors on sensory neurons. The C-type receptor is coupled to 45Ca uptake, whereas the …