The potential role of the orexin reward system in future treatments for opioid drug abuse
Despite a history of more than a century of intense research in drug addiction, with currently
available medication and behavioral therapy, the rate of relapse to drug use is 40–60 …
available medication and behavioral therapy, the rate of relapse to drug use is 40–60 …
Functional roles of orexin/hypocretin receptors in reward circuit
A Haghparast, Z Fatahi, R Arezoomandan… - Progress in Brain …, 2017 - Elsevier
Since its first discovery in 1998, it has become clear that the orexinergic system plays an
important role in regulating a number of functions including food, sex, social connections …
important role in regulating a number of functions including food, sex, social connections …
Behavioural expression of positive anticipation for food or opportunity to play in lambs
C Anderson, J Yngvesson, A Boissy… - Behavioural …, 2015 - Elsevier
Anticipatory behaviours may serve a useful tool in studying positive emotional states in
animals. This study aimed to investigate if lambs express anticipatory behaviours for …
animals. This study aimed to investigate if lambs express anticipatory behaviours for …
D1-and D2-like dopamine receptors in the CA1 region of the hippocampus are involved in the acquisition and reinstatement of morphine-induced conditioned place …
N Assar, D Mahmoudi, A Farhoudian… - Behavioural brain …, 2016 - Elsevier
The hippocampus plays a vital role in processing contextual memories and reward related
learning tasks, such as conditioned place preference (CPP). Among the neurotransmitters in …
learning tasks, such as conditioned place preference (CPP). Among the neurotransmitters in …
Impaired acquisition of nicotine-induced conditioned place preference in fatty acid-binding protein 3 null mice
Nicotine causes psychological dependence through its interactions with nicotinic
acetylcholine receptors in the brain. We previously demonstrated that fatty acid-binding …
acetylcholine receptors in the brain. We previously demonstrated that fatty acid-binding …
Role of dopamine D1-like receptor within the nucleus accumbens in acute food deprivation-and drug priming-induced reinstatement of morphine seeking in rats
F Sadeghzadeh, V Babapour, A Haghparast - Behavioural brain research, 2015 - Elsevier
Dopamine is a predominant neurotransmitter in the nervous system, which plays an
important role in both drug priming-and cue-induced reinstatement of cocaine and heroin …
important role in both drug priming-and cue-induced reinstatement of cocaine and heroin …
Differential effects of intra-accumbal orexin-1 and-2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats
F Sadeghzadeh, P Namvar, FS Naghavi… - Pharmacology …, 2016 - Elsevier
Orexinergic neurons originate from the hypothalamic nuclei, sending projections toward
mesolimbic regions such as the nucleus accumbens (NAc). In this study, an attempt was …
mesolimbic regions such as the nucleus accumbens (NAc). In this study, an attempt was …
Nucleus accumbens dopamine receptors mediate hypothalamus‐induced antinociception in the rat formalin test
A Siahposht‐Khachaki, P Pourreza… - … Journal of Pain, 2017 - Wiley Online Library
Background Lateral hypothalamus (LH) involves in modulation of tonic pain. Regarding the
direct and indirect neural connections between the LH and nucleus accumbens (NA c), we …
direct and indirect neural connections between the LH and nucleus accumbens (NA c), we …
Involvement of D1-and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats.
P Namvar, S Zarrabian, F Nazari-Serenjeh… - Behavioral …, 2019 - psycnet.apa.org
Previous studies on drug abuse have shown that response to drug-associated cues exist
during prolonged abstinence. In succession to previous investigations in our laboratory on …
during prolonged abstinence. In succession to previous investigations in our laboratory on …
[HTML][HTML] Role of orexin-1 receptor within the ventral tegmental area in mediating stress-and morphine priming-induced reinstatement of conditioned place preference …
R Azizbeigi, Z Farzinpour… - Basic and Clinical …, 2019 - ncbi.nlm.nih.gov
Methods: In the current study, a Reinstatement model is used to examine the effects of intra-
VTA administration of SB334867 as an Orexin-1 Receptor (OX1R) antagonist on drug …
VTA administration of SB334867 as an Orexin-1 Receptor (OX1R) antagonist on drug …