A survey of different strategies for chromatographic method development in pharmaceutical
research and development is presented. Owing to the widespread utilization of …

The majority of liquid chromatography (LC) methods are still developed in a conventional
manner, that is, by analysts who rely on their knowledge and experience to make method …

High-performance liquid chromatography (HPLC) simulators are effective method
development tools. The goal of the present work was to design and implement a simple …

Abstract Development of meaningful and reliable analytical assays in the (bio)
pharmaceutical industry can often be challenging, involving tedious trial and error …

Stationary phase gradients formed in a single column housing or by serially connected
columns are the most recently explored subset of non-uniform chromatography. Such non …

Liquid chromatography (LC) is the single largest analytical field in terms of people involved
and money spent. LC is crucial for almost all public and private sectors and the technique …

We introduce a new workflow that relies heavily on chemical quantitative structure-retention
relationship (QSRR) models to accelerate method development for micro/mini-scale high …

Simulation software for liquid chromatography can accelerate method development
capabilities. In two-dimensional chromatography this is particularly attractive because there …

Retention prediction of monoamine neurotransmitters has been compared for the generally
applied linear solvent‐strength model and quadratic polynomial three‐parameter model …

Precisely developed computational methodologies can allow the drug product lifecycle
process to be time-efficient, cost-effective and reliable through a thorough fundamental …