Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors
of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can …

Genetic mutations of phaeochromocytoma (PCC) and paraganglioma (PGL) are mainly
classified into two major clusters. Cluster 1 mutations are involved with the pseudo hypoxic …

Hereditary pheochromocytoma (PCC) is often caused by germline mutations in one of nine
susceptibility genes described to date,,,, but there are familial cases without mutations in …

The transcription factor MYC regulates cell proliferation, transformation, and survival in
response to growth factor signaling that is mediated in part by the kinase activity of ERK2 …

The transcription factor MYC and its related family members MYCN and MYCL have been
implicated in the etiology of a wide spectrum of human cancers. Compared to other …

The c-myc is a proto-oncogene that manifests aberrant expression at high frequencies in
most types of human cancer. C-myc gene amplifications are often observed in various …

Abstract Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are rare
neuroendocrine tumors. About 30% or more of them are thought to be of inherited origin due …

Background: Cancerous inhibitor of protein phosphatase 2A (CIP2A) drives cellular
transformation. The objective of this study was to detect the potential effects of CIP2A in …

Paragangliomas/pheochromocytomas comprise rare tumors that arise from the extra-
adrenal paraganglia, with an incidence of about 2 to 8 per million people each year …

Undifferentiated thyroid carcinoma is one of the most aggressive human cancers with
frequent RAS mutations. How mutations of the RAS gene contribute to undifferentiated …