Cellular senescence and senolytics: the path to the clinic

S Chaib, T Tchkonia, JL Kirkland - Nature medicine, 2022 - nature.com
Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

The landscape of aging

Y Cai, W Song, J Li, Y Jing, C Liang, L Zhang… - Science China Life …, 2022 - Springer
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The quest to slow ageing through drug discovery

L Partridge, M Fuentealba, BK Kennedy - Nature Reviews Drug …, 2020 - nature.com
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

[HTML][HTML] COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

C Sargiacomo, F Sotgia, MP Lisanti - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the
SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory …

Endometrial receptivity in women of advanced age: an underrated factor in infertility

ADS Pathare, M Loid, M Saare, SB Gidlöf… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced
age is one of the critical risk factors for female-related infertility. It is well known that maternal …

The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

L Secomandi, M Borghesan, M Velarde… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Therapy-induced senescence: an “old” friend becomes the enemy

T Saleh, S Bloukh, VJ Carpenter, E Alwohoush… - Cancers, 2020 - mdpi.com
For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Quercetin: antiviral significance and possible COVID-19 integrative considerations

PK Agrawal, C Agrawal… - Natural Product …, 2020 - journals.sagepub.com
Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic
diseases and aging processes in humans, and its antiviral properties have been …

Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization

AS Kulkarni, S Aleksic, DM Berger, F Sierra… - Aging …, 2022 - Wiley Online Library
Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …

Senescent cells: a therapeutic target in cardiovascular diseases

M Suda, KH Paul, T Minamino, JD Miller, A Lerman… - Cells, 2023 - mdpi.com
Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …