Role of cytochrome P450 2C8 in drug metabolism and interactions
During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …
Drug–drug interaction studies: regulatory guidance and an industry perspective
T Prueksaritanont, X Chu, C Gibson, D Cui, KL Yee… - The AAPS journal, 2013 - Springer
Recently, the US Food and Drug Administration and European Medicines Agency have
issued new guidance for industry on drug interaction studies, which outline comprehensive …
issued new guidance for industry on drug interaction studies, which outline comprehensive …
[HTML][HTML] Computational prediction of drug-drug interactions based on drugs functional similarities
Therapeutic activities of drugs are often influenced by co-administration of drugs that may
cause inevitable drug-drug interactions (DDIs) and inadvertent side effects. Prediction and …
cause inevitable drug-drug interactions (DDIs) and inadvertent side effects. Prediction and …
Coproporphyrins in plasma and urine can be appropriate clinical biomarkers to recapitulate drug-drug interactions mediated by organic anion transporting polypeptide …
Y Lai, S Mandlekar, H Shen, VK Holenarsipur… - … of Pharmacology and …, 2016 - ASPET
In the present study, an open-label, three-treatment, three-period clinical study of
rosuvastatin (RSV) and rifampicin (RIF) when administered alone and in combination was …
rosuvastatin (RSV) and rifampicin (RIF) when administered alone and in combination was …
Understanding the critical disposition pathways of statins to assess drug–drug interaction risk during drug development: it's not just about OATP1B1
R Elsby, C Hilgendorf, K Fenner - Clinical Pharmacology & …, 2012 - Wiley Online Library
The use of statins is widespread across disease areas because many patients have
comorbidities. Given that these drugs have become common as comedications, it is …
comorbidities. Given that these drugs have become common as comedications, it is …
Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
Z Shan, X Yang, H Liu, Y Yuan, Y Xiao, J Nan… - Cell Research, 2023 - nature.com
Members of the solute carrier organic anion transporting polypeptide (OATPs) family
function as transporters for a large variety of amphipathic organic anions including …
function as transporters for a large variety of amphipathic organic anions including …
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A
T Prueksaritanont, DA Tatosian, X Chu… - Clinical …, 2017 - Wiley Online Library
A microdose cocktail containing midazolam, dabigatran etexilate, pitavastatin, rosuvastatin,
and atorvastatin has been established to allow simultaneous assessment of a perpetrator …
and atorvastatin has been established to allow simultaneous assessment of a perpetrator …
Dose‐dependent inhibition of OATP1B by rifampicin in healthy volunteers: comprehensive evaluation of candidate biomarkers and OATP1B probe drugs
D Mori, E Kimoto, B Rago, Y Kondo… - Clinical …, 2020 - Wiley Online Library
To address the most appropriate endogenous biomarker for drug–drug interaction risk
assessment, eight healthy subjects received an organic anion transporting polypeptide 1B …
assessment, eight healthy subjects received an organic anion transporting polypeptide 1B …
Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions
The risk assessment of organic anion transporting polypeptide (OATP) 1B1–mediated drug-
drug interactions (DDIs) is an indispensable part of drug development. We previously …
drug interactions (DDIs) is an indispensable part of drug development. We previously …