Introduction: Late-stage functionalization (LSF) can introduce important chemical groups in
the very last steps of the synthesis. LSF has the potential to speed up the preparation of …

Hydroaminoalkylation is a powerful, atom-economic catalytic reaction for the reaction of
amines with alkenes and alkynes. This C–H functionalization reaction allows for the atom …

The catalytic enantioselective construction of C (sp 3)− C (sp 3) bonds remains a substantial
challenge in organic synthesis. One particularly promising approach is the use of transition …

Saturated heterocycles are found in numerous therapeutics and bioactive natural products
and are abundant in many medicinal and agrochemical compound libraries. To access new …

Site-and enantioselective cross-coupling of saturated N-heterocycles and carboxylic acids—
two of the most abundant and versatile functionalities—to form pharmaceutically relevant α …

The direct functionalization of inert C (sp3)‐H bonds to form carbon‐carbon and carbon‐
heteroatom bonds offers vast potential for chemical synthesis and therefore receives …

Deconstructive functionalization involves carbon–carbon (C–C) bond cleavage followed by
bond construction on one or more of the constituent carbons. For example, ozonolysis and …

The generation of attractive scaffolds for drug discovery efforts requires the expeditious
synthesis of diverse analogues from readily available building blocks. This endeavor …

Organolithium reagents are a vital tool in modern organic chemistry, enabling the synthesis
of carbon–carbon bonds. However, due to their high reactivity, low temperatures, inert …

Excising the nitrogen in secondary amines, and coupling the two residual fragments is a
skeletal editing strategy that can be used to construct molecules with new skeletons, but …