Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can
potentially be accomplished using the processes of dedifferentiation, transdifferentiation or …

Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …

A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and
maintaining homeostasis by balancing self-renewal and cell differentiation. The …

Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of
all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns …

Maintenance of the blood system is dependent on dormant haematopoietic stem cells
(HSCs) with long-term self-renewal capacity. After injury these cells are induced to …

White adipose tissue (WAT) is perhaps the most plastic organ in the body, capable of
regeneration following surgical removal and massive expansion or contraction in response …

The classical roadmap of hematopoietic hierarchy has been proposed for nearly 20 years
and has become a dogma of stem cell research for most types of adult stem cells, including …

Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells. Because HSCs must
persist for a lifetime, the balance between their proliferation and quiescence is carefully …

Stem cell niches are defined as the cellular and molecular microenvironments that regulate
stem cell function together with stem cell autonomous mechanisms. This includes control of …