The study of brain development in humans is limited by the lack of tissue samples and
suitable in vitro models. Here, we model early human neural tube development using …

For well over half of the 150 years since the discovery of the neural crest, the special ability
of these cells to function as a source of species‐specific pattern has been clearly …

Sensory placodes and neural crest cells are among the key cell populations that facilitated
the emergence and diversification of vertebrates throughout evolution. Together, they …

Integrin activation contributes to key blood cell functions including adhesion, proliferation
and migration. An essential step in the cell signaling pathway that activates integrin requires …

Coordination of bilateral movements is essential for a large variety of animal behaviors. The
olivocerebellar system is critical for the control of movement, but its role in bilateral …

Inner ear development requires the coordination of cell types from distinct epithelial,
mesenchymal and neuronal lineages. Although we have learned much from animal models …

The inner ear develops from the otic placode, one of the cranial placodes that arise from a
region of ectoderm adjacent to the anterior neural plate called the pre-placodal domain. We …

Age-related neurosensory deficit of the inner ear is mostly due to a loss of hair cells (HCs).
Development of stem cell-based therapy requires a better understanding of factors and …

Producing hair cells of the inner ear is the major goal of ongoing research that combines
advances in developmental and stem cell biology. The recent advent of an inner ear …

Vertebrate cranial sensory organs are derived from region at the border of the anterior
neural plate called the pre-placodal region (PPR). The otic placode, the anlagen of the inner …