In this review article the history of leishmaniasis is discussed regarding the origin of the
genus Leishmania in the Mesozoic era and its subsequent geographical distribution, initial …

Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are
necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant …

Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the
tumor by interfering with specific molecular targets and are currently the focus of anticancer …

The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

Abstract PI3K/AKT signalling is commonly disrupted in human cancers, with AKT being a
central component of the pathway, influencing multiple processes that are directly involved …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Rational target therapy of cancer would benefit from the identification of new targets that can
be easily inhibited by small molecules. An increasing amount of evidence hints at 3 …

PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in
breast cancer. PI3Kα inhibitors are in clinical development and despite promising early …

Since the clinical approval of imatinib, the discovery of protein kinase downregulators
entered a prosperous age. However, challenges still exist in the discovery of kinase …

Protein phosphorylation is one of the most widely observed and important post-translational
modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each …