In higher eukaryotes, enhancers determine the activation of developmental gene
transcription in specific cell types and stages of embryogenesis. Enhancers transform the …

Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …

In higher eukaryotes, the regulation of developmental gene expression is determined by
enhancers, which are often located at a large distance from the promoters they regulate …

Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …

The emergence of whole-genome assays has initiated numerous genome-wide studies of
transcription factor localizations at genomic regulatory elements (enhancers, promoters …

Eukaryotic gene expression is regulated by enhancer–promoter interactions but the
molecular mechanisms that govern specificity have remained elusive. Genome-wide studies …

The spatial organization of chromosomes is involved in regulating the majority of
intranuclear processes in higher eukaryotes, including gene expression. Drosophila was …

Though long non-coding RNAs (lncRNAs) represent a substantial fraction of the Pol II
transcripts in multicellular animals, only a few have known functions. Here we report that the …

Combinatorial interactions among transcription factors (TFs) play essential roles in
generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid …

Understanding how the metazoan genome is used during development and cell
differentiation is one of the major challenges in the postgenomic era. Early studies in …