The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Parkinson's disease (PD) is a neurodegenerative condition characterized by the dopamine
(DA) neuronal loss in the substantia nigra. PD impairs motor controls symptoms such as …

Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …

Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Mitophagy impairment and oxidative stress are cardinal pathological hallmarks in
Parkinson's disease (PD), a common age-related neurodegenerative condition. The specific …

Organisms across taxa face stresses including variable temperature, redox imbalance, and
xenobiotics. Successfully responding to stress and restoring homeostasis are crucial for …

While the analysis of mitochondrial morphology has emerged as a key tool in the study of
mitochondrial function, efficient quantification of mitochondrial microscopy images presents …

Lysosomal impairment is strongly implicated in Parkinson's disease (PD). Among the
several PD-linked genes, the ATP13A2 gene, associated with the PARK9 locus, encodes a …

Autophagy–lysosomal function is crucial for maintaining healthy lifespan and preventing age-
related diseases. The transcription factor TFEB plays a key role in regulating this pathway …

The movement disorder Parkinson's disease (PD) is the second most frequently diagnosed
neurodegenerative disease, and is associated with aging, the environment, and genetic …