Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …

Inflammation is an underlying feature of a variety of human diseases. An important
manifestation of this pathophysiological response is microvascular dysfunction, which …

The microcirculation is highly responsive to, and a vital participant in, the inflammatory
response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit …

In the last decade, numerous studies revealed physiologic and pathophysiologic roles of
platelets beyond haemostasis, a process to prevent and stop bleeding. These include the …

Hematologic abnormalities are frequently encountered in small animal cancer patients, and
may result from the direct effects of tumor growth or from paraneoplastic syndromes. Cancer …

Sepsis can lead to shock, multiple organ failure, and even death. Platelets play an active
role in the pathogenesis of sepsis-induced multiple organ failure. Angiotensin (Ang)-(1–7), a …

Background Previous clinical evidence correlates levels of von Willebrand factor (VWF) and
its cleaving protease ADAMTS13 with outcome in septic patients. No previous studies …

Objective—The platelet glycoprotein Ib-IX (GP Ib-IX) receptor is a well-characterized
adhesion receptor supporting hemostasis and thrombosis via interactions with von …

Sepsis, a systemic inflammatory response to infection, is often accompanied by
abnormalities of blood coagulation. Prior work with a mouse model of sepsis induced by …

Figure 1. Exogenous histones increase the number of platelet-ultra-large von Willebrand
factor (ULVWF) strings (arrows) during parallel-plate flow (700 s-1).(A) Phase contrast …