Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing
of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as …

Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are
a new modality of chemical tools and potential therapeutics to understand and treat human …

Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel–
Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell …

Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Summary von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is
associated with a germline mutation of the VHL tumour suppressor gene on the short arm of …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

Inactivation of the VHL tumor suppressor protein (pVHL) is a common event in clear cell
renal carcinoma, which is the most common form of kidney cancer. pVHL performs many …

Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …