The mammalian host responds to infection with Borrelia spirochetes through a highly
orchestrated immune defense involving innate and adaptive effector functions aimed toward …

Lyme borreliosis is the most prevalent tick-borne disease in the United States, infecting~
476,000 people annually. Borrelia spp. spirochetal bacteria are the causative agents of …

Laser capture microdissection (LCM) coupled with RNA-seq is a powerful tool to identify
genes that are differentially expressed in specific histological tumor subtypes. To better …

Lyme disease, which is caused by infection with Borrelia burgdorferi and related species,
can lead to inflammatory pathologies affecting the joints, heart, and nervous systems …

Background Pediatric central nervous system (CNS) infections are potentially life-
threatening and may incur significant morbidity. Identifying a pathogen is important, both in …

Borrelia bavariensis can invade the central nervous system (CNS) by crossing the blood-
brain barrier (BBB). It is predicted that B. bavariensis evokes numerous signaling cascades …

Pathogen-induced changes in host cell metabolism are known to be important for the
immune response. In this study, we investigated how infection with the Lyme disease …

Background The blood-brain barrier (BBB), a highly regulated interface between the blood
and the brain, prevents blood-borne substances and pathogens from entering the CNS …

Breast cancer is one of the leading causes of death in women worldwide. Recent studies
have demonstrated that inflammation due to infections with microorganisms could play a …

The host immune response to infection is a well-coordinated system of innate and adaptive
immune cells working in concert to prevent the colonization and dissemination of a …