The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

Macrophages are critical mediators of the innate immune response against foreign
pathogens, including bacteria, physical stress, and injury. Therefore, these cells play a key …

Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Background. Conventional anticancer therapies still cause difficulties with selective
eradication and accompanying side effects that reduce patients' quality of life (QOL) …

The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms,
interacts with many proteins and has multiple functions. Numerous therapies are based on …

Glucocorticoids (Gcs) are widely used to treat inflammatory diseases and hematological
malignancies, and despite the introduction of novel anti-inflammatory and anti-cancer …

The nuclear hormone receptor (NR) superfamily comprises approximately 50 evolutionarily
conserved proteins that play major roles in gene regulation by prototypically acting as ligand …

Fatty acid metabolism contributes to energy supply and plays an important role in regulating
immunity. Free fatty acids (FFAs) bind to free fatty acid receptors (FFARs) on the cell surface …

Background The outcome of bullous pemphigoid (BP), the most frequent autoimmune skin-
blistering disease, involves matrix metalloproteinase 9 (MMP-9), IL-17, and IL-23 release …