Recommendations for measuring HIV reservoir size in cure-directed clinical trials
M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
Integration site selection by retroviruses and transposable elements in eukaryotes
Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …
and are widely used as gene-delivery and functional genomics tools. Exploring whether …
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy
Chromosomal integration of genome-intact HIV-1 sequences into the host genome creates a
reservoir of virally infected cells that persists throughout life, necessitating indefinite …
reservoir of virally infected cells that persists throughout life, necessitating indefinite …
Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
TA Wagner, S McLaughlin, K Garg, CYK Cheung… - Science, 2014 - science.org
Antiretroviral treatment (ART) of HIV infection suppresses viral replication. Yet if ART is
stopped, virus reemerges because of the persistence of infected cells. We evaluated the …
stopped, virus reemerges because of the persistence of infected cells. We evaluated the …
[HTML][HTML] HIV-1 integration landscape during latent and active infection
The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent
proviruses. To characterize these latently infected cells, we studied the integration profile of …
proviruses. To characterize these latently infected cells, we studied the integration profile of …
Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers
Increasing evidence suggests that durable drug-free control of HIV-1 replication is enabled
by effective cellular immune responses that may induce an attenuated viral reservoir …
by effective cellular immune responses that may induce an attenuated viral reservoir …
An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients
CA Spina, J Anderson, NM Archin, A Bosque… - PLoS …, 2013 - journals.plos.org
The possibility of HIV-1 eradication has been limited by the existence of latently infected
cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have …
cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have …
Nuclear architecture dictates HIV-1 integration site selection
Long-standing evidence indicates that human immunodeficiency virus type 1 (HIV-1)
preferentially integrates into a subset of transcriptionally active genes of the host cell …
preferentially integrates into a subset of transcriptionally active genes of the host cell …
Eradicating HIV-1 infection: seeking to clear a persistent pathogen
NM Archin, JM Sung, C Garrido… - Nature Reviews …, 2014 - nature.com
Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected
individuals to control infection and live long, productive lives. However, HIV-1 infection …
individuals to control infection and live long, productive lives. However, HIV-1 infection …
Nuclear landscape of HIV-1 infection and integration
M Lusic, RF Siliciano - Nature Reviews Microbiology, 2017 - nature.com
To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …