Managing patients with psoriatic disease: the diagnosis and pharmacologic treatment of psoriatic arthritis in patients with psoriasis

PJ Mease, AW Armstrong - Drugs, 2014 - Springer
Psoriatic arthritis (PsA) is a chronic, systemic inflammatory disease. Up to 40% of patients
with psoriasis will go on to develop PsA, usually within 5–10 years of cutaneous disease …

Neuropilins: expression and roles in the epithelium

JRL Wild, CA Staton, K Chapple… - International journal of …, 2012 - Wiley Online Library
Initially found expressed in neuronal and then later in endothelial cells, it is well established
that the transmembrane glycoproteins neuropilin‐1 (NRP1) and neuropilin‐2 (NRP2) play …

Apremilast mechanism of action and application to psoriasis and psoriatic arthritis

P Schafer - Biochemical pharmacology, 2012 - Elsevier
Psoriasis and psoriatic arthritis are common clinical conditions that negatively impact health-
related quality of life and are linked to serious medical comorbidities. Disease mechanisms …

Association of circulating vascular endothelial growth factor levels with autoimmune diseases: A systematic review and meta-analysis

H Zhan, H Li, C Liu, L Cheng, S Yan, Y Li - Frontiers in immunology, 2021 - frontiersin.org
Background Autoimmune diseases (ADs) are characterized by immune-mediated tissue
damage, in which angiogenesis is a prominent pathogenic mechanism. Vascular …

Podoplanin expression in wound and hyperproliferative psoriatic epidermis: regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22

M Honma, M Minami-Hori, H Takahashi… - Journal of dermatological …, 2012 - Elsevier
BACKGROUND: Podoplanin (PDPN)/T1α/aggrus/PA2. 26 antigen, a transmembranous
glycoprotein, is a well-known lymphatic endothelial marker. Recent evidence indicates that …

Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease

F Benhadou, E Glitzner, A Brisebarre, B Swedlund… - Science …, 2020 - science.org
Psoriasis is a common chronic skin disorder characterized by keratinocyte hyperproliferation
with altered differentiation accompanied by inflammation and increased angiogenesis. It …

Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model

R Panonnummal, M Sabitha - International journal of biological …, 2018 - Elsevier
Methotrexate loaded chitin nanogel (MCNG) was formulated for its topical use in psoriasis.
MCNG was characterized by DLS, TEM and FTIR. The MCNG particles were spherical in …

Abnormal vascular architecture at the placental-maternal interface in placenta increta

F Chantraine, S Blacher, S Berndt… - American journal of …, 2012 - Elsevier
OBJECTIVE: The objective of the study was to characterize the vascular architecture at the
placental-maternal interface in pregnancies complicated by placenta increta and normal …

[HTML][HTML] Dimethylfumarate inhibits angiogenesis in vitro and in vivo: a possible role for its antipsoriatic effect?

M García-Caballero, M Marí-Beffa, MA Medina… - Journal of investigative …, 2011 - Elsevier
The fumaric acid esters (FAEs) have been used for the oral treatment of psoriasis for some
50 years. Given that a persistent and maintained angiogenesis is associated with several …

[HTML][HTML] EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction

E Pivetta, A Capuano, M Vescovo, E Scanziani… - Matrix Biology, 2022 - Elsevier
Alterations in extracellular matrix (ECM) components that modulate inflammatory cell
behavior have been shown to serve as early starters for multifactorial diseases such as …