Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Maintenance of skeletal muscle mass throughout the life course is key for the regulation of
health, with physical activity a critical component of this, in part, due to its influence upon key …

In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

This investigation compared the effect of high‐volume (VOL) versus high‐intensity (INT)
resistance training on stimulating changes in muscle size and strength in resistance‐trained …

This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

I. Overview T HE general characterization of the growth hormone/insulin-like growth factor-I
(GH/IGF-I) system has been established for a considerable length of time, and we will not …

I. Introduction U NTIL recently, there has been little scientific inquiry into the physiological
significance of, and possible therapy for, GH deficiency in adulthood. This was because the …

Growth hormone (GH) is widely used as a performance‐enhancing drug. One of its best‐
characterized effects is increasing levels of circulating insulin‐like growth factor I (IGF‐I) …

Muscle mass declines with aging. Amino acids alone stimulate muscle protein synthesis in
the elderly. However, mixed nutritional supplementation failed to improve muscle mass. We …

Human growth hormone (hGH) is secreted in a pulsatile fashion, generally following a
circadian rhythm. A number of physiological stimuli can initiate hGH secretion, the most …