ADP-ribosylation, is a reversible post-translational modification implicated in major
biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that …

In recent years, induced pluripotent stem cells (iPSCs) have been considered as a
promising approach in the field of regenerative medicine. iPSCs can be generated from …

Thromboembolic events are the main cause of mortality in BCR-ABL1-negative
myeloproliferative neoplasms (MPNs) but their underlying mechanisms are largely …

Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of
all female cancers. The disease shows high intertumoral and intratumoral heterogeneity …

Red blood cells and platelets are anucleate blood components indispensable for oxygen
delivery and hemostasis, respectively. Derivation of these blood elements from induced …

Patient‐derived models, including cell models (organoids and conditionally reprogrammed
cells [CRCs]) and patient‐derived xenografts, are urgently needed for both basic and …

The mainstay of treatment of ß-Thalassemia major includes life-long regular packed red cell
transfusions and iron chelation. With advances in understanding the molecular biology and …

Induced pluripotent stem cells (iPSCs) were first described over a decade ago and are
currently used in various basic biology and clinical research fields. Recent advances in the …

Abstract Beta-thalassemia (β-thal) is a congenital hemoglobinopathy explained by a
decreased level (β+) or absence (βο) of β-globin gene expression. Microcytic hypochromic …

Yamanaka and colleagues revolutionized stem cell biology and regenerative medicine by
observing that somatic cells can be reprogrammed into pluripotent stem cells. Evidence …