The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

We detail a six-stage planar differentiation methodology for generating human pluripotent
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …

Technological advancements in blood glucose monitoring and therapeutic insulin
administration have improved the quality of life for people with type 1 diabetes. However …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …