Genetics of rheumatoid arthritis

L Padyukov - Seminars in immunopathology, 2022 - Springer
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …

B cells in rheumatoid arthritis: pathogenic mechanisms and treatment prospects

F Wu, J Gao, J Kang, X Wang, Q Niu, J Liu… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a common, chronic, systemic autoimmune disease, and its
clinical features are the proliferation of joint synovial tissue, the formation of pannus and the …

Immunopathogenesis of rheumatoid arthritis

GS Firestein, IB McInnes - Immunity, 2017 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

[HTML][HTML] Dietary habits and nutrition in rheumatoid arthritis: can diet influence disease development and clinical manifestations?

C Gioia, B Lucchino, MG Tarsitano, C Iannuccelli… - Nutrients, 2020 - mdpi.com
Rheumatoid arthritis (RA) is a systemic, autoimmune disease characterized by joint
involvement, with progressive cartilage and bone destruction. Genetic and environmental …

Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis

D van der Woude, AHM van der Helm-van - Best practice & research …, 2018 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation,
which affects approximately 1% of the population. The benefit of early recognition and …

Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications

BR England, GM Thiele, DR Anderson, TR Mikuls - Bmj, 2018 - bmj.com
Rheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity
and mortality from cardiovascular disease. Mechanisms linking rheumatoid arthritis and …

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

VM Holers, MK Demoruelle, KA Kuhn… - Nature Reviews …, 2018 - nature.com
Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting

V Malmström, AI Catrina, L Klareskog - Nature Reviews Immunology, 2017 - nature.com
Patients with rheumatoid arthritis can be divided into two major subsets characterized by the
presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of …

Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses

E Fousert, R Toes, J Desai - Cells, 2020 - mdpi.com
Following fifteen years of research, neutrophil extracellular traps (NETs) are widely reported
in a large range of inflammatory infectious and non-infectious diseases. Cumulating …