Pseudokinases: a tribble‐edged sword
L Richmond, K Keeshan - The FEBS Journal, 2020 - Wiley Online Library
Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and
TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis …
TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis …
The critical role of TRIB2 in cancer and therapy resistance
V Mayoral-Varo, L Jiménez, W Link - Cancers, 2021 - mdpi.com
Simple Summary The Tribbles proteins are members of CAMK Ser/Thr protein kinase family.
They are evolutionary conserved pseudokinases found in most tissues of eukaryotic …
They are evolutionary conserved pseudokinases found in most tissues of eukaryotic …
Tribbles-1 expression and its function to control inflammatory cytokines, including interleukin-8 levels are regulated by miRNAs in macrophages and prostate cancer …
C Niespolo, JM Johnston, SR Deshmukh… - Frontiers in …, 2020 - frontiersin.org
The pseudokinase TRIB1 controls cell function in a range of contexts, by regulating MAP
kinase activation and mediating protein degradation via the COP1 ubiquitin ligase. TRIB1 …
kinase activation and mediating protein degradation via the COP1 ubiquitin ligase. TRIB1 …
Control of cell growth and proliferation by the tribbles pseudokinase: Lessons from Drosophila
Simple Summary Tribbles pseudokinases represent a sub-branch of the CAMK
(Ca2+/calmodulin-dependent protein kinase) subfamily and are associated with disease …
(Ca2+/calmodulin-dependent protein kinase) subfamily and are associated with disease …
TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ
S Zhou, S Liu, C Lin, Y Li, L Ye, X Wu, Y Jian, Y Dai… - Oncogene, 2020 - nature.com
Radioresistance becomes the major obstacle to reduce tumor recurrence and improve
prognosis in the treatment of esophageal squamous cell carcinoma (ESCC). Thus new …
prognosis in the treatment of esophageal squamous cell carcinoma (ESCC). Thus new …
Structure vs. Function of trib1—myeloid neoplasms and beyond
Simple Summary Tribbles proteins possess the structure of protein kinases but function by
forming protein complexes rather than phosphorylating substrates. Here we review the …
forming protein complexes rather than phosphorylating substrates. Here we review the …
[HTML][HTML] Kojic Acid Derivative as an Antimitotic Agent That Selectively Kills Tumour Cells
G Pichiri, M Piludu, T Congiu, N Grandi, P Coni… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: The primary method used to pharmacologically arrest cancer
development and its metastasis is to disrupt the cell division process. There are a few …
development and its metastasis is to disrupt the cell division process. There are a few …
Tribbles pseudokinases in colorectal cancer
BI Ferreira, B Santos, W Link, AL De Sousa-Coelho - Cancers, 2021 - mdpi.com
Simple Summary The Tribbles family of pseudokinases controls a wide number of processes
during cancer on-set and progression. However, the exact contribution of each of the three …
during cancer on-set and progression. However, the exact contribution of each of the three …
TRIB1 modulates transcriptional programming in breast cancer cells to regulate cell proliferation
HD McMillan, EK Papachristou, J Hazlett, S Omarjee… - bioRxiv, 2023 - biorxiv.org
Abstract The pseudokinase Tribbles Homolog 1 (TRIB1) is a known driver of tumorigenesis
in acute myeloid leukemia and is encoded upstream of the oncogene MYC at the 8q24 …
in acute myeloid leukemia and is encoded upstream of the oncogene MYC at the 8q24 …
Nanobodies identify an activated state of the TRIB2 pseudokinase
SA Jamieson, M Pudjihartono, CR Horne, JS Viloria… - Structure, 2022 - cell.com
Summary Tribbles proteins (TRIB1–3) are pseudokinases that recruit substrates to the COP1
ubiquitin ligase. TRIB2 was the first Tribbles ortholog to be implicated as a myeloid leukemia …
ubiquitin ligase. TRIB2 was the first Tribbles ortholog to be implicated as a myeloid leukemia …